% Yield and % ee of (S)-2-[(R)-hydroxy(4-nitrophenyl)methyl] cyclohexan-1-one and (S)-2-[(R)-hydroxy(4-methoxyphenyl)methyl] cyclohexan-1-one.

Entry	Catalysts	(S)-2-[(R)-hydroxy(4-nitrophenyl)methyl] cyclohexan-1-one		(S)-2-[(R)-hydroxy(4-methoxyphenyl)methyl] cyclohexan-1-one
		% Yield	% ee	% Yield	% ee
1	No catalysta	67.2	0	1.1	0
2	Prolineb	41.8	73.2	83.0	99.4
3	P1	53.8	22.2	21.5	0
4	CuP1	18.1	87.2	84.7	95.5
5	P2	66.5	22.9	25.8	0
6	CuP2	31.5	88.7	3.3	68.2
7	P3	41.9	94.4	84.4	97.5
8	CuP3	40.2	80.2	29.6	91.0
9	P4c	55.0	98.0	91.2	98.4
10	CuP4	50.5	0	22.1	0
11	P5	56.6	—	39.6	99.0
12	CuP5	50.7	0	21.2	94.4

^aNegative control.

^bPositive control.

^cP4 was observed to be the best catalyst for both the aldol reactions, followed by P3. The copper-peptides (exceptional for CuP4) catalyzed both the aldol reactions with higher enantioselectivity (94–98%) and yield of products as compared to proline.