Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 1;114(5):771–774. doi: 10.1093/jnci/djab058

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 1. — Polygenic risk score (PRS) phenome-wide association results and absolute lifetime risk of prostate cancer in men of European ancestry. (A) Manhattan plot for phenome-wide association study (PheWAS) of 1093 disease categories (based on billing codes) with the prostate cancer PRS in men of European ancestry. The horizontal line indicates phenome-wide–level significance (2-sided P = 4.6 × 10⁻⁵) using Bonferroni correction. Adjustments were made for age at blood collection, genotyping platform, and the first 10 principal components. Odds ratios (ORs) are reported as per 1-SD increase in the PRS. (B) Cumulative incidence of prostate cancer (overall and by Gleason score) for men of European ancestry included in the cohort analysis, stratified by PRS quartile.