Table 1.
Odds ratio with 95% confidence interval for the association between PRS and prostate cancer from the case-control analysis
| PRS category | European ancestry |
African ancestry |
||
|---|---|---|---|---|
| Cases/controls | ORa (95% CI) | Cases/controls | ORb (95% CI) | |
| (1554/10 918) | (67/457) | |||
| By quartiles | ||||
| 0%-25% | 177/2943 | 0.45 (0.38 to 0.54) | 8/123 | 0.59 (0.24 to 1.35) |
| 25%-75% | 700/5536 | 1.00 (Ref.) | 28/234 | 1.00 (Ref.) |
| 75%-100% | 677/2440 | 2.46 (2.18 to 2.78) | 31/100 | 2.66 (1.44 to 4.98) |
| By deciles | ||||
| 0%-10% | 55/1193 | 0.34 (0.25 to 0.46) | 1/52 | 0.15 (0.01 to 0.92) |
| 10%-20% | 79/1168 | 0.51 (0.39 to 0.67) | 6/46 | 1.21 (0.37 to 3.70) |
| 20%-30% | 98/1149 | 0.66 (0.52 to 0.85) | 5/48 | 0.73 (0.21 to 2.32) |
| 30%-40% | 100/1148 | 0.68 (0.53 to 0.87) | 5/47 | 0.59 (0.16 to 1.93) |
| 40%-60% | 285/2210 | 1.00 (Ref.) | 10/94 | 1.00 (Ref.) |
| 60%-70% | 166/1080 | 1.21 (0.98 to 1.50) | 5/48 | 0.77 (0.21 to 2.49) |
| 70%-80% | 183/1064 | 1.42 (1.15 to 1.74) | 7/45 | 1.31 (0.42 to 3.90) |
| 80%-90% | 223/1024 | 1.87 (1.54 to 2.29) | 13/39 | 2.27 (0.85 to 6.16) |
| 90%-100% | 365/883 | 3.89 (3.24 to 4.68) | 15/38 | 3.81 (1.48 to 10.19) |
a
Adjusted for age at blood collection, genotyping platform, and the first 10 principal components. CI = confidence interval; OR = odds ratio; PRS = polygenic risk score.
b
Adjusted for age at blood collection, genotyping platform, and the first 2 principal components.