Table 1.
Characteristics of included studies that assessed the risk of death in patients with hepatocellular carcinoma*
| Ref. | First author | Year | City | Country | Study period | Design | N | Therapy | T2DM | N events | No T2DM | N events |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 17 |
Toyoda |
2001 |
Ogaki |
Japan |
Jan 1990-Jun 1999 |
Retro |
581 |
Mix |
92 |
39 |
489 |
209 |
| 18 |
Poon |
2002 |
Hong Kong |
China |
Jan 1989-Sep 1999 |
Retro |
525 |
HR |
62 |
29 |
463 |
229 |
| 19 |
Li |
2003 |
Beijing |
China |
Jan 1998-Dec 2001 |
Retro |
225 |
No surg |
28 |
10 |
197 |
63 |
| 20 |
Huo |
2004 |
Taipei |
Taiwan |
Apr 1996-March 2001 |
Retro |
255 |
HR |
41 |
23 |
214 |
85 |
| 312 |
No surg |
79 |
39 |
233 |
85 |
|||||||
| 21 |
Komura |
2007 |
Ishikawa |
Japan |
Jun 1987-May 2004 |
Retro |
90 |
HR |
30 |
17 |
60 |
14 |
| 22 |
Sumie |
2007 |
Fukuoka |
Japan |
Jan 1994-Dec 2000 |
Retro |
118 |
Mix |
39 |
22 |
79 |
34 |
| 23 |
Kawamura |
2008 |
Tokyo |
Japan |
Jan 1980-Dec 2006 |
Retro |
40 |
HR/RFA |
18 |
6 |
22 |
7 |
| 24 |
Huo |
2009 |
Taipei |
Taiwan |
Jan 2002-Dec 2008 |
Retro |
1713 |
Mix |
392 |
235 |
1321 |
674 |
| 25 |
Feng |
2010 |
Tainan City |
Taiwan |
Aug 2007-Jun 2008 |
Retro |
52 |
TACE |
14 |
2 |
38 |
6 |
| 26 |
Chen |
2011 |
Taichung |
Taiwan |
Jul 2003-Jun 2009 |
Retro |
135 |
RFA |
53 |
26 |
82 |
19 |
| 28 |
Shau |
2012 |
Taipei |
Taiwan |
Jan 2003-Dec 2004 |
Retro |
931 |
Mix |
185 |
96 |
746 |
248 |
| 29 |
Ting |
2012 |
Taipei |
Taiwan |
Jan 2000-Dec 2008 |
Retro |
389 |
HR |
117 |
59 |
272 |
106 |
| 30 |
Hosokawa |
2013 |
Tokyo |
Japan |
Jan 1999-Dec 2007 |
Retro |
344 |
RFA |
159 |
19 |
185 |
12 |
| 31 |
Bhat |
2014 |
Rochester |
USA |
Jan 2005-Jun 2011 |
Retro |
701 |
NA |
263 |
170 |
438 |
257 |
| 32 |
Masood |
2014 |
Lahore |
Pakistan |
Jun 2006-Dec 2012 |
Retro |
282 |
Mix |
97 |
50 |
185 |
95 |
| 33 |
Tsai |
2014 |
Taichung |
Taiwan |
Jan 2000- Dec 2010 |
Retro |
5924 |
HR |
2962 |
41 |
2962 |
35 |
| 34 |
Wang |
2014 |
Nanning |
China |
Jun 2003-Feb 2011 |
Retro |
505 |
HR |
134 |
1 |
371 |
8 |
| 35 |
Zhang |
2014 |
Wuhan |
China |
Mar2002-Aug 2012 |
Retro |
138 |
TACE |
34 |
34 |
104 |
102 |
| 36 |
Chan |
2016 |
Taipei |
Taiwan |
Jan 1995-Dec 2011 |
Retro |
26 267 |
HR |
6663 |
3929 |
19 604 |
10 183 |
| 91 482 |
No surg |
21 449 |
18 931 |
70 034 |
61 539 |
|||||||
| 39 |
Yoshida |
2017 |
Tokyo |
Japan |
Jan 2001-Dec 2013 |
Retro |
224 |
HR |
112 |
41 |
112 |
33 |
| 40 |
Li |
2018 |
Hangzhou |
China |
Jan 2008-Dec 2015 |
Retro |
11 048 |
LT |
3136 |
760 |
7912 |
1730 |
| 41 |
Liu |
2018 |
Beijing |
China |
Jan 2005-Dec 2012 |
Retro |
308 |
RFA |
64 |
34 |
244 |
172 |
| 43 |
Liu |
2020 |
Shanghai |
China |
Apr 2011-Jan 2017 |
Retro |
1052 |
TACE |
289 |
161 |
763 |
379 |
| Total | - | - | - | - | - | - | 144 566 | - | 36 689 | 24 815 | 107 877 | 25 957 |
*Abbreviations: Ref – reference; N – number; T2DM – type 2 diabetes mellitus; retro – retrospective; HR – hepatic resection; RFA – radiofrequency ablation; TACE – trans-arterial chemo-embolization; LT – liver transplantation.