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. 2022 Apr 25;10(4):e35475. doi: 10.2196/35475

Table 5.

Top 10 important features for pN2 lymph node metastasis prediction.

Rank LRa L2-LRb RFc LGBMd All

Feature Weight Feature Weight Feature Weight Feature Weight
1 pGGOe,f –10.383 CEAg 3.530 CEA 0.229 CEA 46.0 CEA
2 CEA 6.010 CA125h 3.067 CA125 0.094 Age 23.3 Solid nodulef
3 CA125 4.728 pGGOf –1.799 Solid nodulef 0.094 Solid nodulef 18.8 CA125
4 Solid nodulef 3.683 Solid nodulef 1.773 MLNSAf,i 0.073 TLAf,j 17.6 Age
5 TLAf –2.701 Age –1.315 MLNLAf,k 0.072 TSAf,l 15.1 MLNLAf
6 Age –1.908 SCCAgm 0.944 TLAf 0.054 CA125 13.3 TLAf
7 SCCAg 1.763 MLNLAf 0.896 TSAf 0.048 Cyfra211n 12.9 pGGOf
8 mGGOf,o 1.759 Pleural indentationf 0.836 Cyfra211 0.038 NSEp 12.7 SCCAg
9 RMLf,q –1.729 Cardiovascular disease 0.807 SCCAg 0.037 MLNLAf 11.6 Lobulationf
10 TSAf 1.601 Lobulationf 0.725 Lobulationf 0.036 SCCAg 9.0 TSAf

aLR: logistic regression.

bL2-LR: L2-logistic regression.

cRF: random forest.

dLGBM: LightGBM.

epGGO: pure ground glass opacity.

fFeatures recorded in computed tomography reports.

gCEA: carcinoembryonic antigen.

hCA125: carbohydrate antigen 12-5.

iMLNSA: mediastinal lymph node short axis.

jTLA: tumor long axis.

kMLNLA: mediastinal lymph node long axis.

lTSA: tumor short axis.

mSCCAg: squamous cell carcinoma antigen.

nCyfra211: cytokeratin 19-fragments.

omGGO: mixed ground glass opacity.

pNSE: neuron-specific enolase.

qRML: right middle lobe.