Figure 1.

Risk factors for immune-related adverse events. CTLA4, Cytotoxic T-Lymphocyte Antigen 4; PD-1, Programmed Cell death-1; PD-L1, Programmed death-ligand 1; irAE, immune-related adverse events; HER2i, human epidermal growth factor receptor 2 inhibitors; VEGF, Vascular endothelial growth factor; TKI, Tyrosine Kinase Inhibitor; HLA, Human leukocyte antigen; AML, acute myeloid leukemia; MDS, myelodysplastic syndromes; BMI, body mass index; ECOG, Eastern Cooperative Oncology Group; ILD, interstitial lung disease; COPD, Chronic obstructive pulmonary disease; RT, radiation therapy; CKD, chronic kidney disease; AKI, acute kidney injury; PPI, Proton-pump inhibitors; NSAID, nonsteroidal anti-inflammatory drugs; ACE, angiotensin-converting enzyme inhibitors; ARB, angiotensin receptor blockers; ^#, there is weak evidence for these risk factors.