Table 1.
An overview of BMP knockout rodent models.
| Bmp ligand deleted | Type of deletion | Phenotype | Reference |
|---|---|---|---|
| BMP2 | Global | Lethal - abnormal cardiac development | (72) |
| Conditional (chondrocytes) | Chondrodysplasia | (73) | |
| Conditional (skeletally mature mice) | Trabecular bone loss | (74) | |
| Diminished osteoid formation | |||
| Impaired both osteoblast and osteoclast function | |||
| BMP4 | Global | Lethal - abnormal mesodermal differentiation | (75) |
| Conditional (chondrocytes) | Minor effects on cartilage phenotype | (73) | |
| BMP5 | Nonsense mutation (naturally occurred) | Short ear phenotype and brachypodism due to the slowed formation of new cartilage | (76) |
| BMP6 | Global | Minor sternal defects | (77) |
| BMP7 | Global | Underdeveloped kidney mesenchyme, no eye development | (78) |
| Skeletal patterning defects | (79) | ||
| Lethal due to the kidney failure |