FIG. 5.
Kinetics of DFO in tissues of rats treated with aerosolized DFO. Uninfected, nonimmunosuppressed rats were exposed to aerosolized DFO for up to 2 h. The techniques used for generation of the DFO-containing aerosol and exposure of rats are described in the text. Concentrations of DFO in all tissues rose rapidly during exposure and then dropped when exposure ended at 2 h. After a 1-h exposure, the concentration in the lung was approximately equal to the peak concentration in the lung after a bolus i.p. injection of 1,000 mg of DFO kg−1. One animal was used for each time point.