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. 2022 Mar 9;3(2):2100056. doi: 10.1002/ggn2.202100056

Figure 2.

Figure 2

The micro to macro scale of GxE interactions. At the micro level, the host genetics and epigenetics interact to generate the transcriptome and allostatic processes, which manifest at the individual level of host–virus interaction, reflected by the host immune response. Those micromolecular level interactions then interact with or are impacted by the host's behavioral responses, medical interventions, health‐care access and systems, and other SDoH factors.