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. 2022 Mar 9;3(2):2100056. doi: 10.1002/ggn2.202100056

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© 2022 The Authors. Advanced Genetics published by Wiley Periodicals LLC

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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GxSDoH interactions conceptual framework. SDoH encompass personal behavioral, physical‐environmental, social‐cultural, clinical, and health‐care systems factors, which are all interacting with each other. In addition to host genomics, the totality of SDoH or each component of the SDoH interacts with virus genetics, host virus interactions and COVID‐19 clinical outcomes. The virus genetics and host genomics contribute to the host virus interactions. The COVID‐19 clinical outcomes are influenced by the impact of SDoH, host virus interaction and host genomics, and vice versa.