Table 1.
Geometric mean IgG concentrations, GMC [95% CI] expressed as BAU/mL for wild‐type (WT) spike proteins (SFL and RBD) and geometric mean titers, GMT [95% CI] of neutralizing antibodies (NAb) against WT virus and three variants of concern Delta (B.1.617.2), Beta (B.1.351), and Omicron (B.1.1.529) in elderly (n = 7–9) and health care workers (HCW) 21–42 (n = 7) or 43–77 (n = 8) days after booster mRNA vaccination (third dose of Comirnaty)
| Anti‐S IgG BAU/mL | NAb to SARS‐CoV‐2 | ||||||
|---|---|---|---|---|---|---|---|
| Days post booster | SFL [95% CI] | RBD [95% CI] | WT [95% CI] | Delta [95% CI] | Beta [95% CI] | Omicron [95% CI] | |
| Elderly | 21–42 |
65 [35–120] n = 9 |
43 [20–90] n = 9 |
180 [55–560] n = 7 |
24 [5.8–100] n = 7 |
12 [3.3–44] n = 7 |
6.7 [2.7–17] n = 7 |
| HCW | 21–42 |
120 [52–270] n = 7 |
62 [29–130] n = 7 |
290 [130–660] n = 7 |
140 [77–250] n = 7 |
64 [37–110] n = 7 |
24 [12–50] n = 7 |
| 43–77 |
140 [50–380] n = 8 |
84 [34–200] n = 8 |
420 [180–1000] n = 8 |
150 [48–450] n = 8 |
78 [22–280] n = 8 |
41 [14–115] n = 8 |
|
Each sample was tested a technical duplicate in each experiment and the experimental precision was confirmed by two positive control samples in each independent experiment.
Correction added on 8th April 2022, after first online publication: display of Table 1 has been updated.