TABLE 4.
Gray et al. 18 | Bertrand et al. 32 | Perl et al. 30 | Selma‐Royo et al. 29 | Shimabukuro et al. 33 | Collier et al. 16 | Low et al. 35 | McLaurin‐Jiang et al. 36 | Kadali et al. b , 34 | |
---|---|---|---|---|---|---|---|---|---|
N (pregnant and/or lactating individuals) | 105 | 175 | 84 | 51 | 12 273 | 45 | 88 | 1828 | 38 |
Injection site soreness/Pain | 61 (58.1) | 150 (85.7) | 34 (40.5) | N/A | 11 274 (91.9) | N/A | 57 (includes swelling) (64.8) | 1312 (71.8) | 37 (97.4) |
Injection site reaction/Rash | 1 (1.0) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Headache | 36 (34.3) | 109 (62.3) | N/A | 20 (39.2) | 6800 (55.4) | N/A | N/A | 1002 (54.8) | 19 (50.0) |
Muscle aches/Pain | 53 (50.5) | 112 (64.0) | N/A | N/A | 6638 (54.1) | N/A | N/A | 941 (51.5) | 13 (34.2) |
Fatigue | 55 (52.4) | 124 (70.9) | 28 (33.3) | N/A | 8772 (71.5) | N/A | 54 (61.4) | 1177 (64.4) | 22 (57.9) |
Fever/Chills | 37 (35.2) | N/A | N/A | N/A | N/A | N/A | 38 (43.2) | N/A | N/A |
Allergic reaction | 1 (1.0) | N/A | N/A | N/A | N/A | N/A | 5 (0.3) | N/A | |
Anaphylaxis | N/A | N/A | N/A | N/A | N/A | N/A | 0 (0.0) | 4 (0.2) | N/A |
Fever | N/A | 51 (29.1) | 10 (11.9) | 16 (11.9) | 4242 (34.6) | 11 (24.4) | 386 (21.1) | 6 (15.8) | |
Chills | N/A | 91 (52.0) | N/A | N/A | 4502 (36.7) | N/A | N/A | 808 (44.2) | 18 (47.4) |
Injection site redness | N/A | 18 (10.3) | N/A | N/A | 660 (5.4) | N/A | N/A | N/A | N/A |
Rash (body) | N/A | 2 (1.1) | N/A | N/A | 36 (0.3) | N/A | N/A | N/A | 4 (10.5) |
Injection site swelling | N/A | 21 (12.0) | N/A | N/A | 1462 (11.9) | N/A | N/A | N/A | N/A |
Injection site itching | N/A | 13 (7.4) | N/A | N/A | 302 (2.5) | N/A | N/A | N/A | N/A |
Nausea | N/A | 31 (17.7) | N/A | N/A | 3265 (26.6) | N/A | 1 (1.1) | N/A | 11 (28.9) |
Joint pain | N/A | 47 (26.9) | N/A | N/A | 3138 (25.6) | N/A | N/A | N/A | 3 (7.9) |
Abdominal pain | N/A | 7 (4.0) | N/A | N/A | 717 (5.8) | N/A | N/A | N/A | N/A |
Diarrhea | N/A | 6 (3.4) | N/A | N/A | 609 (5.0) | N/A | N/A | N/A | 0 (0.0) |
Vomiting | N/A | 5 (2.9) | N/A | N/A | 558 (4.5) | N/A | N/A | N/A | 1 (2.6) |
Change in milk supply (more milk) | N/A | 7 (4.0) | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Change in milk supply (less milk) | N/A | 20 (11.4) | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Change in milk color | N/A | 2 (1.1) | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Abbreviations: N/A, not applicable.
Values are given as number (percentage).
Only 31/38 received two doses and adverse effect was not specified after each dose.