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. 2021 Nov 13;156(3):406–417. doi: 10.1002/ijgo.14008

TABLE 4.

Local and systemic maternal adverse effects after dose 2 of mRNA‐based vaccines a

Gray et al. 18 Bertrand et al. 32 Perl et al. 30 Selma‐Royo et al. 29 Shimabukuro et al. 33 Collier et al. 16 Low et al. 35 McLaurin‐Jiang et al. 36 Kadali et al. b , 34
N (pregnant and/or lactating individuals) 105 175 84 51 12 273 45 88 1828 38
Injection site soreness/Pain 61 (58.1) 150 (85.7) 34 (40.5) N/A 11 274 (91.9) N/A 57 (includes swelling) (64.8) 1312 (71.8) 37 (97.4)
Injection site reaction/Rash 1 (1.0) N/A N/A N/A N/A N/A N/A N/A N/A
Headache 36 (34.3) 109 (62.3) N/A 20 (39.2) 6800 (55.4) N/A N/A 1002 (54.8) 19 (50.0)
Muscle aches/Pain 53 (50.5) 112 (64.0) N/A N/A 6638 (54.1) N/A N/A 941 (51.5) 13 (34.2)
Fatigue 55 (52.4) 124 (70.9) 28 (33.3) N/A 8772 (71.5) N/A 54 (61.4) 1177 (64.4) 22 (57.9)
Fever/Chills 37 (35.2) N/A N/A N/A N/A N/A 38 (43.2) N/A N/A
Allergic reaction 1 (1.0) N/A N/A N/A N/A N/A 5 (0.3) N/A
Anaphylaxis N/A N/A N/A N/A N/A N/A 0 (0.0) 4 (0.2) N/A
Fever N/A 51 (29.1) 10 (11.9) 16 (11.9) 4242 (34.6) 11 (24.4) 386 (21.1) 6 (15.8)
Chills N/A 91 (52.0) N/A N/A 4502 (36.7) N/A N/A 808 (44.2) 18 (47.4)
Injection site redness N/A 18 (10.3) N/A N/A 660 (5.4) N/A N/A N/A N/A
Rash (body) N/A 2 (1.1) N/A N/A 36 (0.3) N/A N/A N/A 4 (10.5)
Injection site swelling N/A 21 (12.0) N/A N/A 1462 (11.9) N/A N/A N/A N/A
Injection site itching N/A 13 (7.4) N/A N/A 302 (2.5) N/A N/A N/A N/A
Nausea N/A 31 (17.7) N/A N/A 3265 (26.6) N/A 1 (1.1) N/A 11 (28.9)
Joint pain N/A 47 (26.9) N/A N/A 3138 (25.6) N/A N/A N/A 3 (7.9)
Abdominal pain N/A 7 (4.0) N/A N/A 717 (5.8) N/A N/A N/A N/A
Diarrhea N/A 6 (3.4) N/A N/A 609 (5.0) N/A N/A N/A 0 (0.0)
Vomiting N/A 5 (2.9) N/A N/A 558 (4.5) N/A N/A N/A 1 (2.6)
Change in milk supply (more milk) N/A 7 (4.0) N/A N/A N/A N/A N/A N/A N/A
Change in milk supply (less milk) N/A 20 (11.4) N/A N/A N/A N/A N/A N/A N/A
Change in milk color N/A 2 (1.1) N/A N/A N/A N/A N/A N/A N/A

Abbreviations: N/A, not applicable.

a

Values are given as number (percentage).

b

Only 31/38 received two doses and adverse effect was not specified after each dose.