TABLE 2.
Relationship between laboratory findings of pregnant women and severity of COVID‐19 a
| Laboratory findings | Overall (n = 258) | Mild and moderate (n = 206) | Severe (n = 43) | Critical (n = 9) | P |
|---|---|---|---|---|---|
| Hemoglobin levels | 11.1 ± 1.6 | 11.09 ± 1.7 | 11.8 ± 1.3 | 10.35 ± 1.2 | 0.01 |
| SpO2 | 95.1 ± 3.6 | 96.6 ± 1.1 | 91.5 ± 4.2 | 83.0 ± 5.8 | 0.001 |
| Leukopenia | |||||
| Yes | 23 (8.9) | 17 (8.3) | 4 (9.3) | 2 (22.2) | 0.3 |
| No | 235 (91.1) | 189 (91.7) | 39 (90.7) | 7 (77.8) | |
| Lymphopenia | |||||
| Yes | 78 (30.6) | 55 (27.1) | 16 (37.2) | 7 (77.8 | 0.003 |
| No | 177 (69.4) | 148 (72.9) | 27 (62.8) | 2 (22.2) | |
| Thrombocytopenia | |||||
| Yes | 49 (19.1) | 40 (19.6) | 6 (14.0) | 3 (33.3) | 0.3 |
| No | 207 (80.9) | 164 (80.4) | 37 (86) | 6 (66.7) | |
| Elevated ALT (>45 U/L) | |||||
| Yes | 77 (30.2) | 47 (23.0) | 24 (57.1) | 6 (66.7) | 0.001 |
| No | 178 (69.8) | 157 (77.0) | 18 (42.9) | 3 (33.3) | |
| Elevated AST (>35 U/L) | |||||
| Yes | 57 (22.4) | 37 (18.1) | 17 (40.5) | 3 (33.3) | 0.005 |
| No | 198 (87.6) | 167 (81.9) | 25 (59.5) | 6 (66.7) | |
| ESR (mm/h; normal range 0·0–15·0) | |||||
| Normal | 6 (2.6) | 5 (2.8) | 1 (2.4) | 0 (0.0) | 0.9 |
| Increased | 224 (97.4) | 175 (97.2) | 40 (97.6) | 9 (100.0) | |
| CRP (mg/L; normal range 0.0–5.0) | |||||
| Normal | 24 (10.3) | 21 (11.3) | 3 (7.9) | 0 (0.0) | 0.001 |
| Increased | 209 (89.7) | 165 (88.7) | 35 (92.1) | 9 (100.0) | |
| Confirmatory test done (SARS‐CoV‐2 quantitative RT‐PCR) | |||||
| Positive | 240 (93.0) | 192 (93.2) | 39 (90.7) | 9 (100.0) | 0.8 |
| Not detected | 3 (1.2) | 3 (1.5) | 0 (0.0) | 0 (0.0) | |
| Suspected | 11 (4.3) | 8 (3.9) | 3 (7.0) | 0 (0.0) | |
| Not done | 4 (1.6) | 3 (1.5) | 1 (2.3) | 0 (0.0) | |
| CT findings | |||||
| Ground‐glass opacities | 58 (22.5) | 28 (13.6) | 21 (48.8) | 9 (100.0) | 0.001 |
| Normal | 17 (6.6) | 17 (8.3) | 0 (0.0) | 0 (0.0) | |
| Not done | 183 (70.9) | 161 (78.2) | 22 (51.2) | 0 (0.0) | |
| COVID‐19 investigational treatments | |||||
| Remdesivir | |||||
| Yes | 43 (16.7) | 17 (8.3) | 19 (44.2) | 7 (77.8) | 0.001 |
| No | 215 (83.3) | 189 (91.7) | 24 (55.8) | 2 (22.2) | |
| Azithromycin | |||||
| Yes | 95 (36.8) | 60 (29.1) | 26 (60.5) | 9 (100.0) | 0.001 |
| No | 163 (63.2) | 146 (70.9) | 17 (39.5) | 0 (0.0) | |
| Ceftriaxone | |||||
| Yes | 125 (48.4) | 84 (40.8) | 32 (74.4) | 9 (100.0) | 0.001 |
| No | 133 (51.6) | 122 (59.2) | 11 (25.6) | 0 (0.0) | |
| Hydroxychloroquine | |||||
| Yes | 34 (13.2) | 25 (12.1) | 3 (7.0) | 6 (66.7) | 0.001 |
| No | 224 (86.8) | 18 (87.9) | 40 (93.0) | 3 (33.3) | |
| Convalescent plasma | |||||
| Yes | 6 (2.3) | 0 (0.0) | 3 (7.0) | 3 (33.3) | 0.001 |
| No | 252 (97.7) | 206 (100.0) | 40 (93.0) | 6 (66.7) | |
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C‐reactive protein; CT, computed tomography; ESR, erythrocyte sedimentation rate; RT‐PCR, reverse transcriptase‐reverse polymerase chain reaction.
a
Values are given as number (percentage) or mean ± SD.