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. 2022 Apr 26;13:858036. doi: 10.3389/fmicb.2022.858036

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Copyright © 2022 Barroso, de Jesus, da Silva, Batista, Laguna, Coelho-Rocha, Vital, Fernandes, Cardoso, Ferreira, Martins, Drumond, Mancha-Agresti, Birbrair, Barh and Azevedo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lactobacillus delbrueckii CIDCA 133 mitigates 5-FU-induced epithelial architecture damage. (A) Histopathological images of mouse ileum (objective: × 20, scale 100 μm), (B) histopathological score, (C) villus height, (D) crypt depth, (E) villus height to crypt depth ratio, and (F) small intestine length. Different letters (A–C) indicate statistically significant differences (p < 0.05) by Kruskal–Wallis test followed by Dunn’s post hoc test (B) or ANOVA followed by Tukey’s post hoc test (C–F). Geometric symbols show animal numbers evaluated in each experimental group. ns indicates no significant difference (p > 0.05).