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. 2022 Apr 26;10:862294. doi: 10.3389/fcell.2022.862294

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Copyright © 2022 Lu, Li, Cao, Ying, Tao, Xiong, Hu, Yang, Qiao, Peng, Zhu, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FAMscore and immune infiltration. (A) mIF staining of biomarkers on the surface of immune cells infiltrated into tumors. 1: CD8 staining; 2: CD56 staining; 3: HLA-DR (red) and CD68 (green) staining; and 4: reconstructed image including all biomarkers. (B) Density of infiltrating immune cells in tumor parenchyma from the AHJU cohort, stratified by the FAMscore level. (C) Abundance of infiltrating immune cells in gastric cancer tissues from TCGA calculated by xCell based on transcriptome, stratified by the FAMscore level. mIF: multiple immunofluorescence; AHJU: Affiliated Hospital of Jiangsu University; TCGA: The Cancer Genome Atlas.