TABLE 5.
Comparison between women admitted for COVID‐19 illness and women admitted for other medical indications (excluding isolation): Pregnancy, delivery, and neonatal outcomes a
| Admitted for COVID‐19 illness (n = 148) | Admitted for other medical indication (excluding isolation) (n = 382) | P value | |
|---|---|---|---|
| Major maternal morbidity | |||
| Required ventilation | 30 (20.3) | 10 (2.6) | <0.0001 |
| Adult respiratory distress syndrome | 28 (18.9) | 5 (1.3) | <0.0001 |
| Other | 26 (17.6) | 24 (6.3) | <0.0001 |
| Septicemia | 9 (6.1) | 9 (2.4) | 0.03 |
| Renal failure | 8 (5.4) | 8 (2.1) | 0.03 |
| Pulmonary oedema | 6 (4.1) | 6 (1.6) | 0.03 |
| Pregnancy outcome | |||
| Miscarriage/ectopic pregnancy/molar pregnancy | 6 (4.1) | 25 (6.5) | ** |
| Termination of pregnancy | 1 (0.7) | 1 (0.3) | ** |
| Delivery | 141 (95.3) | 356 (93.2) | ** |
| Delivery outcome | N = 141 | N = 356 | P value |
| Gestational age at time of delivery (weeks) | 130; 37.0 ± 3.5 | 336; 37.0 ± 3.4 | 0.56 |
| 22–27 | 2 (1.5) | 9 (2.7) | |
| 28–31 | 7 (5.4) | 17 (5.1) | |
| 32–36 | 40 (30.8) | 95 (28.3) | |
| ≥37 | 81 (62.3) | 215 (64.0) | |
| Final mode of delivery | n = 115 | n = 349 | 0.33 |
| Normal/breech/assisted vaginal delivery | 37 (32.2) | 134 (38.4) | |
| Cesarean delivery | 78 (67.8) | 215 (61.6) | |
| Primary indication for cesarean delivery: leading indications | n = 78 | n = 215 | |
| Maternal medical condition | 24 (30.8) | 3 (1.4) | |
| Fetal distress | 22 (28.2) | 69 (32.1) | |
| Previous cesarean delivery | 12 (15.4) | 70 (32.6) | |
| Failure of labor to progress | 6 (7.7) | 9 (4.2) | |
| Pre‐eclampsia/eclampsia | 5 (6.4) | 17 (7.9) | |
| Timing of COVID infection and delivery | n = 136 | n = 346 | |
| COVID‐19 >7 days before delivery | 71 (52.2) | 95 (27.5) | |
| COVID‐19 within 7 days before delivery | 48 (35.3) | 173 (50.0) | |
| COVID‐19 within 7 days after delivery | 10 (7.4) | 65 (18.8) | |
| COVID‐19 >7 days after delivery | 7 (5.1) | 13 (3.8) | |
| Neonatal outcome | Admitted for COVID‐19 illness (n = 143) | Admitted for other medical indication (excluding isolation) (n = 361) | P value |
| Birth weight (g) | 127; 2809 ± 713 | 347; 2883 ± 783 | 0.36 |
| <1000 | 2 (1.6) | 7 (2.0) | |
| 1000–1499 | 5 (3.9) | 12 (3.5) | |
| 1500–2499 | 32 (25.2) | 75 (21.6) | |
| ≥2500 | 88 (69.3) | 253 (72.9) | |
| Congenital anomaly | 5 (3.5) | 11 (3.0) | 0.62 |
| Perinatal death | 10 (7.0) | 24 (6.6) | 0.68 |
| Primary cause of perinatal death | |||
| Stillbirth | 5 (50.0) | 20 (83.3) | |
| Complications of prematurity | 2 (20.0) | 2 (8.3) | |
| Birth asphyxia | 0 (0.0) | 1 (4.2) | |
| Congenital abnormality | 1 (10.0) | 0 (0.0) | |
| Unknown cause of neonatal death | 0 (0.0) | 1 (4.2) | |
| Other | 2 (20.0) | 0 (0.0) | |
| Admission to neonatal high care/intensive care unit | 44 (31.9) | 108 (31.7) | |
| Neonates without complications | 96 (69.6) | 263 (77.1) | |
| Neonates with ≥1 complication | 27 (19.6) | 77 (22.6) | |
| Respiratory distress syndrome | 23 (16.7) | 51 (15.0) | |
| Other | 4 (2.9) | 22 (6.5) | |
| Severe jaundice requiring phototherapy | 6 (4.3) | 16 (4.7) | |
| Severe infection, e.g. septicemia, meningitis | 0 (0.0) | 12 (3.5) | |
| Neonatal encephalopathy | 0 (0.0) | 5 (1.5) | |
| Necrotizing enterocolitis | 1 (0.7) | 1 (0.3) | |
| Intraventricular hemorrhage | 1 (0.7) | 1 (0.3) | |
| Chronic lung disease | 0 (0.0) | 1 (0.3) | |
a
Values are given as number (percentage) or number; mean ± SD.