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. 2022 Apr 26;15:822129. doi: 10.3389/fnmol.2022.822129

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Copyright © 2022 Yang, Yin, Wang, Sun, Bian, Zhang, Li, Cao, Li, Ebrahimi-Fakhari, Yang, Meisler and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PC Scn8a mutant mice exhibit histological changes in cerebellum. (A,B) Abnormal PC morphology and gradual reduced PC number and molecular layer thickness in Scn8a mutant cerebellum (Scale bar upper row 200 μm. bottom row 100 μm). (C,D) The quantification of PC density and the quantification of PC soma area was performed in the IV–V. PC loss was not apparent until 5 months of age, and showed ongoing loss till 9 months (C). At 9 months, mutant Purkinje cell size decreased significantly (D). (E) The thickness of the molecular layer (ML) was normal in mutant cerebellum at 4 months of age, whereas it decreased afterward at 5 months (n ≥ 3 per group. Data shown are means ± SEM. **P < 0.01, ***P < 0.001, two-way ANOVA, Bonferroni's post-hoc analysis).