Figure 4.

Elevation of anxiety in Scn8a PC mutant mice. (A) Schematic of light-dark transition box. In the light–dark preference test, PC Scn8a mutant mice spent significantly less time in the light room (B) and entered it less often than controls (C). (n = 15 for control and n = 13 for mutant). (D) Representative elevated plus maze tracking plots and diagram illustrates locations of open and closed arms of the maze. Mutant mice demonstrated decreased time spent in the open arms (E), and less frequently enter into the open arms (F) of the elevated plus maze (Control: n = 13 Mutant: n = 16). **P < 0.01, ***P < 0.001. All P-values by the Student's unpaired t-test.