Figure 6.

Abnormal social and repetitive behaviors and impaired reversal learning in PC Scn8a mutant mice. (A) Mutant mice spent comparable time sniffing non-social stimuli whereas less time sniffing social odor cues (n = 11 per group). (B) Reduced sociability of KO mice is indicated by reduced time interacting with a female conspecific (Control: n = 8; Mutant: n = 10). (C) PC Scn8a mutant mice spent more time self-grooming (Control: n = 10; Mutant: n = 11). (D,E) On Day 1 to Day 3, mutants display normal acquisition learning of the escape platform location in the water T maze as indicated by total correct trials (D) and trials needed for 5 consecutive correct responses (E). However, on reversal day 1 and day 2, PC Scn8a mutant mice have significantly fewer correct trials (D), and take more trials to achieve five consecutive correct responses (Control: n = 9, Mutant: n = 12). RD, Reversal Day. Data shown are means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, Two-way ANOVA, Bonferroni post-hoc analysis in (A), Student's unpaired t-test in (B–E).