Table 1.
Reported desmethylbromethalin tissue levels and clinical outcomes in dogs.
| Bromethalin dose mg/kg | Neurological signs | DMB level ng/g | Death | Reference | |
|---|---|---|---|---|---|
| 3 Exp. Beagles | 6.25 | YES | FAT 49,58,325 | YES | Dorman et al. (9) |
| Beagle | NA | Found dead* | FAT 390 | YES | Romano et al. (18) |
| Case 1 | NA | YES | FAT <0.1 | NO | |
| Case 2 | NA | YES | FAT >280 | YES | |
| Norwich Terrier | NA | YES | SERUM 0.5 | NO | Lyons et al. (14) |
| Pit Bull Terrier | 0.17** | NO | SERUM 1–4*** | NO | Heggem-Perry et al. (22) |
| Case 3 | NA | YES | SERUM 25–100 | NO |
*
normal within 24 h of death.
**
owner reported.
***
Limit of detection.
Analysis in Dorman et al. (9) is quantitative; all other analyses are semiquantitative based on limited internal control samples.