Table 3.
Human Leucocyte Antigen (HLA) alleles in patients with RP with and without GD
| Patients with GD (N = 5) | Patients without GD (N = 88) | P-value* | Odds ratio [95% confidence interval] | |
|---|---|---|---|---|
| HLA-A | ||||
| 02:01 | 2 (20%) | 19 (10.8%) | 0.31 | 2.01 [0.29–9.78] |
| 02:06 | 1 (10%) | 19 (10.8%) | 1.00 | 0.92 [0.040–6.46] |
| 02:07** | 1 (10%) | 4 (2.3%) | 0.24 | 4.70 [0.18–40.87] |
| 11:01 | 1 (10%) | 27 (15.3%) | 1.00 | 0.61 [0.027–4.12] |
| 24:02 | 3 (30%) | 55 (31.3%) | 1.00 | 0.94 [0.20–3.67] |
| 26:01 | 0 (0%) | 12 (6.8%) | 1.00 | 0 [0.00–6.01] |
| 26:03 | 1 (10%) | 4 (2.3%) | 0.24 | 4.70 [0.18–40.87] |
| 31:01 | 2 (20%) | 19 (10.8%) | 0.31 | 2.06 [0.29–9.78] |
| 33:03 | 0 (0%) | 14 (8.0%) | 1.00 | 0 [0.00–5.97] |
| HLA-B | ||||
| 07:02 | 0 (0%) | 10 (5.7%) | 1.00 | 0 [0.00–7.14] |
| 15:01 | 2 (20%) | 18 (10.2%) | 0.30 | 2.18 [0.31–10.48] |
| 35:01* | 1 (10%) | 18 (10.2%) | 1.00 | 0.98 [0.043–6.93] |
| 39:01 | 0 (0%) | 7 (4.0%) | 1.00 | 0 [0.00–11.88] |
| 40:01 | 0 (0%) | 11 (6.3%) | 1.00 | 0 [0.00–6.51] |
| 40:02 | 1 (10%) | 12 (6.8%) | 0.52 | 1.51 [0.065–11.84] |
| 40:06 | 0 (0%) | 4 (2.3%) | 1.00 | 0 [0.00–21.06] |
| 44:03 | 0 (0%) | 10 (5.7%) | 1.00 | 0 [0.00–7.14] |
| 46:01* | 1 (10%) | 4 (2.3%) | 0.24 | 4.70 [0.18–40.87] |
| 48:01 | 0 (0%) | 4 (2.3%) | 1.00 | 0 [0.00–21.06] |
| 51:01† | 2 (20%) | 14 (8.0%) | 0.21 | 2.87 [0.40–14.55] |
| 52:01 | 1 (10%) | 16 (9.1%) | 1.00 | 1.11 [0.049–8.07] |
| 54:01 | 1 (10%) | 18 (10.2%) | 1.00 | 1.00 [0.043–6.93] |
| 55:02 | 0 (0%) | 6 (3.4%) | 1.00 | 0.98 [0.00–15.36] |
| 59:01 | 0/10 (0%) | 5/176 (2.8%) | 1.00 | 0 [0.00–17.83] |
| 67:01*** | 1/10 (10%) | 5/176 (2.8%) | 0.29 | 3.75 [0.15–36.33] |
| HLA-Cw | ||||
| 01:02 | 2 (20%) | 33 (18.8%) | 1.00 | 1.08 [0.16–5.03] |
| 03:03 | 3 (30%) | 26 (14.8%) | 0.19 | 2.46 [0.52–9.91] |
| 03:04 | 1 (10%) | 22 (12.5%) | 1.00 | 0.78 [0.035–5.36] |
| 04:01 | 0 (10%) | 9 (5.1%) | 1.00 | 0 [0.00–8.21] |
| 07:02 | 1 (10%) | 28 (15.9%) | 1.00 | 0.59 [0.026–3.94] |
| 08:01 | 0 (0%) | 10 (5.7%) | 1.00 | 0 [0.00–7.14] |
| 12:02 | 1 (10%) | 17 (9.7%) | 1.00 | 1.04 [0.046–7.46] |
| 14:02 | 2 (20%) | 11 (6.3%) | 0.15 | 3.71 [0.51–20.24] |
| 14:03 | 0 (0%) | 10 (5.7%) | 1.00 | 0 [0.00–7.14] |
| 15:02 | 0 (0%) | 4 (2.3%) | 1.00 | 0 [0.00–21.06] |
| HLA-DRB1 | ||||
| 01:01 | 0 (0%) | 9 (5.1%) | 1.00 | 0 [0.00–8.21] |
| 04:03 | 0 (0%) | 6 (3.4%) | 1.00 | 0 [0.00–15.36] |
| 04:05 | 0 (0%) | 31 (17.6%) | 0.22 | 0 [0.0–2.14] |
| 04:06 | 0 (0%) | 9 (5.1%) | 1.00 | 0 [0.00–8.21] |
| 04:07 | 1 (10%) | 2 (1.1%) | 0.15 | 9.38 [0.30–129.97] |
| 04:10 | 0 (0%) | 3 (1.7%) | 1.00 | 0 [0.00–32.00] |
| 08:02 | 1 (10%) | 7 (4.0%) | 0.36 | 2.66 [0.11–20.53] |
| 08:03 | 0 (0%) | 11 (6.3%) | 1.00 | 0 [0.00–6.51] |
| 09:01 | 2 (20%) | 22 (12.5%) | 0.62 | 1.74 [0.25–8.14] |
| 11:01 | 0 (0%) | 5 (2.8%) | 1.00 | 0 [0.00–17.83] |
| 12:01 | 2 (20%) | 6 (3.4%) | 0.061 | 6.92 [0.89–38.52] |
| 13:02 | 0 (0%) | 9 (5.1%) | 1.00 | 0 [0.00–8.21] |
| 14:03* | 0 (0%) | 2 (1.1%) | 1.00 | 0 [0.00–63.42] |
| 14:05 | 1 (10%) | 0 (0%) | 0.054 | Inf [0.93–Inf] |
| 14:54 | 1 (10%) | 8 (4.5%) | 0.40 | 2.32 [0.096–18.37] |
| 15:01 | 1 (10%) | 15 (8.5%) | 0.60 | 1.19 [0.052–8.78] |
| 15:02 | 0 (0%) | 16 (9.1%) | 1.00 | 0 [0.00–5.00] |
| 16:02*** | 1 (10%) | 5 (2.8%) | 0.29 | 3.75 [0.15–36.33] |
| HLA-DQB1 | ||||
| 03:01 | 2 (20%) | 16 (9.1%) | 0.25 | 2.48 [0.35–12.21] |
| 03:02 | 1 (10%) | 23 (13.1%) | 1.00 | 0.74 [0.033–5.06] |
| 03:03 | 3 (30%) | 26 (14.8%) | 0.19 | 2.46 [0.52–9.91] |
| 04:01 | 0 (0%) | 31 (17.6%) | 0.22 | 0 [0.00–2.14] |
| 04:02 | 1 (10%) | 5 (2.8%) | 0.29 | 3.75 [0.15–36.33] |
| 05:01 | 0 (0%) | 9 (5.1%) | 1.00 | 0 [0.00–8.21] |
| 05:02*** | 1 (10%) | 12 (6.8%) | 0.52 | 1.51 [0.065–11.85] |
| 05:03 | 1 (10%) | 1 (0.057%) | 0.10 | 18.49 [0.46–751.60] |
| 06:01 | 0 (0%) | 27 (15.3%) | 0.36 | 0 [0.00–2.56] |
| 06:02 | 1 (10%) | 15 (8.5%) | 0.60 | 1.19 [0.052–8.78] |
| 06:04 | 0 (0%) | 8 (4.5%) | 1.00 | 0 [0.00–9.71] |
| HLA-DPB1 | ||||
| 02:01 | 1 (10%) | 46 (26.1%) | 0.46 | 0.32 [0.014–2.07] |
| 02:02 | 2 (20%) | 4 (2.3%) | 0.035 | 10.41 [1.23–65.38] |
| 03:01 | 0 (0%) | 5 (2.8%) | 1.00 | 0 [0.00–17.83] |
| 04:01 | 0 (0%) | 9 (5.1%) | 1.00 | 0 [0.00–8.21] |
| 04:02 | 0 (0%) | 9 (5.1%) | 1.00 | 0 [0.00–8.21] |
| 05:01* | 5 (50%) | 83 (47.2%) | 1.00 | 1.12 [0.31–4.05] |
| 09:01 | 1 (10%) | 11 (6.3%) | 0.50 | 1.66 [0.071–13.38] |
| 13:01 | 1 (10%) | 3 (1.7%) | 0.20 | 6.27 [0.22–63.23] |
The frequency of HLA-DPB1*02:02 was higher in the RP patients with GD than in the patients without GD
Alleles of which frequencies in general Japanese were over 2%, alleles found among the RP patients with Graves’ disease and alleles which have been reported to be associated with autoimmune thyroiditis, relapsing polychondritis, and Bechet disease were listed
P-value was obtained by Fisher’s exact test
GD: Graves’ disease, Inf: infinity
*Risk allele for Graves’ disease, **risk allele for Hashimoto thyroiditis, ***risk allele for relapsing polychondritis, †risk allele for Bechet disease