Influence of quercetin on oxidative stress parameters in experimental animalsa.
| Group | Blood | Renal cortex | ||||
|---|---|---|---|---|---|---|
| GSH (nmol mg−1) | SOD (units per mg) | MDA (μmol L−1) | GSH (nmol mg−1) | SOD (units per mg) | MDA (μmol L−1) | |
| NC | 20.92 ± 5.99 | 61.44 ± 7.47 | 1.69 ± 0.67 | 67.27 ± 18.31 | 9.75 ± 1.60 | 0.31 ± 0.58 |
| DN | 7.56 ± 1.79* | 41.50 ± 4.81* | 2.67 ± 0.69* | 40.16 ± 5.02* | 6.52 ± 0.55* | 0.45 ± 0.09* |
| DN + LQ | 14.27 ± 0.94*# | 51.36 ± 7.12*# | 1.67 ± 0.29# | 58.62 ± 18.40# | 8.11 ± 0.56*# | 0.29 ± 0.13# |
| DN + HQ | 19.12 ± 0.36# | 55.40 ± 3.75# | 1.52 ± 0.42# | 59.54 ± 11.69# | 9.67 ± 1.08# | 0.27 ± 0.07# |
a
Values represented mean ± SD (n = 5 per group). NC, normal control; DN, diabetic nephropathy; LQ, low dose quercetin (50 mg kg−1 d−1); HQ, high dose quercetin (100 mg kg−1 d−1); GSH, glutathione; SOD, superoxide dismutase; MDA, malondialdehyde. *P < 0.05 vs. NC, #P < 0.05 vs. DN.