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. 2022 May 10;21:111. doi: 10.1186/s12943-022-01549-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — TRAF1 is modulated by m6A RNA methylation. A The m6A contents of mRNAs in 78S and 78R cells. B The m6A contents of mRNAs in OSS and OSR cells. C The m6A contents of mRNAs in CDX-S and CDX-R tissues. D and E MeRIP assays for m6A-modified TRAF1 in 78S and 78R cells. F Protein level of m6A modification–associated genes in sunitinib-sensitive/resistant cells. G The protein level of METTL14 in CDX-S and CDX-R. H The protein level of METTL14 in clinical patient samples. I and J The positive correlation of METTL14 and TRAF1 in RNA level. K The positive correlation of METTL14 and TRAF1 in protein level. L Identification of m6A abundances on TRAF1 transcripts in METTL14 knockdown cell line and control via m6A-sequence. M and N The m6A levels of TRAF1 with modulation of METTL14