Fig. 7.

TRAF1 maintained sunitinib resistance in a METTL14-dependent manner. A and B CCK8 rescue experiments in 78S cells and 78R cells C and D Colony formation rescue experiments in 78S cells and 78R cells E and F Tube formation rescue experiments in 78S cells and 78R cells. G The protein levels of HIF-1a, Caspase3 and cleaved caspase3 were measured by western blot analysis in 78S cells transfected with lentiviruses carrying TRAF1 and/or sh-METTL14. H The protein levels of HIF-1a, Caspase3 and cleaved caspase3 were measured by western blot analysis in 78R cells transfected with lentiviruses carrying METTL14 and/or sh-TRAF1