Table 2.

Prognostic associations of MALAT1 expression and colorectal cancer outcomes in the external validation population.

Factors and Subgroups	No. of Patients	MALAT1 Expression Level		Overall Survival		Disease Free Survival
		Lower (ref.)	Higher	PS-Adjusted HR (95% CI)	P-value	PS-Adjusted HR (95% CI)	P-value
Overall	596	298	298	0.971 (0.676-1.396)	0.876	1.177 (0.878-1.577)	0.276
Gender
Female	274	137	137	1.103 (0.646-1.881)	0.720	1.290 (0.835-1.994)	0.252
Male	322	161	161	0.839 (0.508-1.383)	0.491	1.087 (0.729-1.619)	0.683
Age (yr)
< 60	174	92	82	1.680 (0.713-3.960)	0.235	1.513 (0.835-2.743)	0.172
≥ 60	422	206	216	0.880 (0.587-1.319)	0.536	1.099 (0.783-1.542)	0.585
BMI (kg/m2)
Normal weight	195	116	79	1.195 (0.654-2.186)	0.562	1.450 (0.869-2.421)	0.155
Overweight or Obese	401	182	219	0.987 (0.627-1.555)	0.956	1.136 (0.794-1.625)	0.486
Tumor Location
Right Colon	250	130	120	0.856 (0.514-1.426)	0.551	0.896 (0.574-1.397)	0.627
Left Colon	225	111	114	1.232 (0.645-2.352)	0.528	1.477 (0.907-2.406)	0.117
Rectum	121	57	64	0.867 (0.348-2.160)	0.759	1.354 (0.673-2.727)	0.396
AJCC Stage
1	106	57	49	0.942 (0.149-5.970)	0.950	1.836 (0.553-6.100)	0.321
2	222	113	109	0.445 (0.213-0.926)	0.030	0.792 (0.467-1.344)	0.388
3	179	92	87	1.144 (0.618-2.116)	0.669	1.211 (0.727-2.015)	0.462
4	89	36	53	1.082 (0.545-2.150)	0.822	1.342 (0.756-2.382)	0.314
CEA (ng/mL)
≤ 5	263	143	120	0.837 (0.419-1.672)	0.615	1.139 (0.677-1.915)	0.623
> 5	333	155	178	1.037 (0.675-1.594)	0.869	1.172 (0.821-1.673)	0.381
History of polyps
No	407	212	195	1.027 (0.671-1.571)	0.903	1.126 (0.800-1.586)	0.497
Yes	189	86	103	0.814 (0.403-1.647)	0.568	1.301 (0.734-2.307)	0.368