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. 2022 Apr 26;13:831194. doi: 10.3389/fimmu.2022.831194

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Copyright © 2022 Wang, Zhang, Yang, Wang, Guo, Sun, Zhou, Su, Ge and Feng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased CD3⁺ conventional T cells in FI^hi patients with severe COVID-19. (A) Pseudo-bulk analysis and clustering of the samples collected from 12 patients with severe COVID-19. The patients were evaluated by chest CT imaging system at discharge, and FI values were given. Based on the median value (0.0567) of FI, the patients were divided into two groups, FI^lo (P01-04, P08-09) and FI^hi (P05-07, P10-12). (B) UMAP visualization of PBMC clusters. (C). Dot plot showing the row-scaled expression of selected signature genes for each cluster. (D) Cell composition varied among all patients studied. (E). Increased conventional T-cell proportion in FI^hi cohorts.