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. 2022 Apr 26;13:831194. doi: 10.3389/fimmu.2022.831194

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Copyright © 2022 Wang, Zhang, Yang, Wang, Guo, Sun, Zhou, Su, Ge and Feng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased percentage of activated CD4⁺ T cells and Treg cells in FI^hi patients with severe COVID-19. (A) UMAP visualization of T-cell clusters. (B) Dot plot showing the row-scaled expression of selected signature genes for each cluster. (C) Comparison of the proportions of T-cell clusters between FI ^lo and FI^hi COVID patients. (D) Heatmap of the transcription factors of each cluster, with mean area under the curve (AUC) scores are shown. (E) Volcano plot showing DEGs (p-values < 0.05) in the comparison of each T-cell cluster derived from FI^lo and FI^hi patients. (F) GSEA analysis of differentially expressed genes (DEGs) in T cells in the comparison of FI^lo and FI^hi patients with severe COVID-19. (G) Heatmap comparison of the transcription factors in T cells derived from FI^lo and FI^hi patients.