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. 2022 Apr 26;13:831194. doi: 10.3389/fimmu.2022.831194

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Copyright © 2022 Wang, Zhang, Yang, Wang, Guo, Sun, Zhou, Su, Ge and Feng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Attenuated global antiviral response in FI^hi patients with severe COVID-19. (A) UMAP visualization of NK cell clusters. (B) Heatmap showing the row-scaled expression of selected signature genes for each cluster. (C) Volcano plot showing DEGs (p-values < 0.05) in the comparison of each NK cell cluster derived from FI^lo and FI^hi patients. The dot lines show 1.5-fold cutoff. (D) GSEA analysis of DEGs in NK cells in the comparison of FI^lo and FI^hi patients with severe COVID-19. (E) UMAP visualization of monocyte clusters. (F) Heatmap showing the row-scaled expression of selected signature genes for each cluster. (G) GSEA analysis of DEGs in monocytes in the comparison of FI^lo and FI^hi patients with severe COVID-19. (H) Volcano plot showing DEGs (p-values < 0.05) in the comparison of each monocyte cluster derived from FI^lo and FI^hi patients. The dot lines show 1.5-fold cutoff.