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. 2022 Apr 26;13:831194. doi: 10.3389/fimmu.2022.831194

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Copyright © 2022 Wang, Zhang, Yang, Wang, Guo, Sun, Zhou, Su, Ge and Feng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Weakened interaction between T cells and other cell types in FI^hi patients with severe COVID-19. (A) Heatmap shows the number of ligand and receptor pairs co-expressed among various cell types and cell clusters in the patients with severe COVID-19. The results derived from FI^lo and FI^hi patients were separately shown. (B) Lists of the names of the cell clusters. (C) Bubble plot shows mean expression of ligand and receptor pairs co-expressed between monocyte clusters (Mo1 and Mo4) and CTL cluster T11. The results derived from FI^lo and FI^hi patients were separately shown.