Table 3.
Clinical characteristics at recurrence, 12 months and last follow-up
| At time of recurrence | R group | NR group | |||
|---|---|---|---|---|---|
| All | Surveillance Bx. | Diagnostic Bx. | Clinical diagnosis | ||
| Number of patients | 43 | 24 | 13 | 6 | – |
| on prednisone, N (%) | 39 (90.7%) | 23 (95.8%) | 11 (84.6%) | 5 (83.3%) | – |
| on RAAS blockade, N (%) | 27 (62.8%) | 16 (66.7%) | 7 (53.8%) | 4 (66.7%) | – |
| Median eGFR (ml/min/1.73m2) [IQR] | 53.4 [43.4, 64] | 55.7 [43.4, 63.5] | 44.1 [32.6, 53.8] | 61.1 [48.4, 70.2] | – |
| Median proteinuriaa (mg/mmol) [IQR] | 26.5 [13.8, 49] | 19.5 [12.2, 35] | 68.5 [30, 113] | 14.5 [12.5, 36.8] | – |
| Patients with glomerular hematuria | 24 (55.8%) | 11 (45.8%) | 7 (53.8%) | 6 (100%) | |
| At 12 months post-transplant follow-up visit | |||||
| Number of patientsb | 29 | 21 | 6 | 2 | 130 |
| on prednisone, N (%) | 26 (89.7%) | 19 (90.5%) | 6 (100%) | 1 (50%) | 102 (78.5%) |
| on RAAS blockade, N (%) | 16 (55.2%) | 12 (57.1%) | 2 (33.3%) | 2 (100%) | 75 (57.7%) |
| Median eGFR (ml/min/1.73m2) [IQR] | 49.8 [38.5, 70.5] | 49.8 [40.2, 69.7] | 42.2 [22.9, 50.8] | 82.4 [80, 84.9] | 56.8 [43.5, 68.5] |
| Median proteinuriaa (mg/mmol) [IQR] | 18 [8, 37.6] | 13 [7, 24.6] | 37.9 [23.5, 177.7] | 34.1 [19.6, 48.5] | 11 [6.2, 19.9] |
| Patients with glomerular hematuria | 9 (31%) | 6 (28.6%) | 2 (33.3%) | 1 (50%) | 0 |
| At last follow-up visitc | |||||
| Number of patients | 43 | 24 | 13 | 6 | 118 |
| on prednisone, N (%) | 34 (79.1%) | 17 (70.8%) | 11 (84.6%) | 6 (100%) | 76 (64.4%) |
| on RAAS blockade, N (%) | 31 (72.1%) | 21 (87.5%) | 6 (46.2%) | 4 (66.7%) | 76 (64.4%) |
| Median time to last follow-up visit (years) [IQR] | 7 [5, 8.8] | 7 [5.6, 8.3] | 6.6 [2.7, 8.9] | 7.1 [7, 7.7] | 6 [4.3, 8] |
| Median eGFR (ml/min/1.73m2) [IQR] | 46 [24.7, 65.3] | 59.5 [38.4, 65.8] | 19.6 [7.8, 46] | 54.9 [43.4, 65.9] | 52.6 [38.3, 68.9] |
| Median proteinuriaa (mg/mmol) [IQR] | 27.9 [9.2, 108.5] | 11.9 [9.2, 29.1] | 69.7 [15.3, 140] | 47.6 [18.9, 101.2] | 12.5 [6.7, 28.5] |
| Patients with glomerular hematuria | 22 (51.2%) | 9 (37.5%) | 8 (61.5%) | 5 (83.3%) | 0 |
Abbreviations:TX transplantation, IQR interquartile range, IgAN IgA nephropathy, R recurrence, NR non-recurrence, RAAS renin-angiotensin-aldosterone system, eGFR estimated glomerular filtration rate, Bx biopsy
aProteinuria is defined as protein to creatinine ratio
bThere are two patients without 12 months post-transplant follow-up due to death or graft failure
cThere are five patients with last follow-up visit within first 12 months post-transplant