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. 2022 May 10;11:26. doi: 10.1186/s40164-022-00279-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Targeted transcriptomic analysis of tumor-infiltrating mouse leukocytes reveals upregulation of proinflammatory cytokine and chemokine genes upon NI-1701 treatment. Mouse CD45⁺ tumor-infiltrating leukocytes were sorted from tumors 14 days after treatment initiation with NI-1701 or hIgG1 control and submitted to Nanostring transcriptomic analysis using the mouse Myeloid Innate Immunity panel (n = 4 mice per group) a Volcano plot of differentially expressed genes in tumor-infiltrating leukocytes between hIgG1 versus NI-1701. Vertical grey lines correspond to absolute log2 fold change > 0.76 (i.e., fold-change > 1.7) and horizontal dot line correspond to a p value of p = 0.05. Grey zone corresponds to statistically non-significant changes and red and blue dots to significantly upregulated and downregulated genes, respectively. b Heatmap depicting row z scores of normalized mRNA count of significantly up-regulated and down-regulated genes with fold change > 1.7