Table 2.

Overview of taxonomic alterations in case–control studies on the gut microbiota in PBC

Reference	Study population	Biological source	Sequencing technique	Enriched in PBC	Depleted in PBC
Chen et al., 2020* [62]	65 PBC; 109 HC	Feces	16S, V3–V4	Enterobacteriaceae genus (unknown), Prevotella, Veillonella, Fusobacterium, Haemophilus, Streptococcus, Clostridiaceae genus (unknown), Pseudomonas, Citrobacter, Lactobacillus, Salmonella, Clostridium, Klebsiella, Sneathia	Mogibacteriaceae genus (unknown), Blautia, Christensenellaceae genus (unknown), Butyricimonas, Akkermansia, Odoribacter, Dialister, Rikenellaceae genus (unknown), Oscillospira, Faecalibacterium, Phascolarctobacterium, Sutterella, Clostridiales genus (unknown), Barnesiellaceae genus (unknown), Bacteroides
Tang et al., 2018* [99]	60 PBC; 80 HC	Feces	16S, V3–V4	Klebsiella, Lactobacillus, Clostridium, Pseudomonas, Haemophilus, Streptococcus, Veillonella, Enterobacteriaceae genus (unknown)	Oscillospira, Faecalibacterium, Sutterella, Bacteroides

*Cohorts overlap partially.

HC, healthy controls; PBC, primary biliary cholangitis.