Fig. 2.

Cancer animal models over the years. The animal model of cancer was first introduced in 1918, but the beginning of today’s models was in 1951 with the development of the CDX models, but the development of other models led to competition for a more suitable model with more efficiency. The beginning of the twenty-first century can be considered the beginning of the flourishing of animal models of cancer. CDX model won the competition between the CDX and GEMME models because of its availability and is still the first choice in many studies. But the remarkable thing is that at the beginning of the second decade of the twenty-first century, PDX models have attracted attention and are being used in various studies with considerable speed. Data obtained from the PubMed database. GEMMs genetically engineered mouse models, PDX patient-derived xenograft, CDX Cell Line-Derived Xenograft model)