Investigation of substrate scope for the synthesis of amino-acid based benzimidazoles.
| |||
|---|---|---|---|
| Entry | Amino acid | Product | Yield |
| 1 | Boc-Leu-OH (18a) |
|
96% |
| 2 | Boc-Ileu-OH (18b) |
|
95% |
| 3 | Boc-Val-OH (18c) |
|
96% |
| 4 | Boc-Pro-OH (18d) |
|
99% |
| 5 | Boc-Tyr(OBn)-OH (18e) |
|
84% |
| 6 | Boc-Ser(OBn)-OH (18f) |
|
84% |
| 7 | Boc-Cys(SBn)-OH (18g) |
|
99% |
| 8 | Boc-Thr(OBn)-OH (18h) |
|
94% |
| 9 | Boc-Lys(Boc)-OH (18i) |
|
99% |
| 10 | Boc-Asp(OBn)-OH (18j) |
|
90% |
| 11 | Boc-Glu(OBn)-OH (18k) |
|
80% |
| 12 | Boc-Asn-OH (18l) |
|
96% |
| 13 | Boc-Gln-OH (18m) |
|
96% |
| 14 | Boc-Phe-OH (18n) |
|
99% |