Figure 1.

Overview of RNA N⁶-methyladenosine (m⁶A) modification. The m⁶A modification is modulated by m⁶A “writers”, “erasers”, and “readers”. m⁶A “writers” are methylase complexes including METTL3, METTL14, ZC3H13, RBM15, VIRMA, HAKAI, WTAP, and METTL16. “Erasers” are demethylases (FTO, ALKHB5) that remove methyl groups. The m⁶A-containing RNAs are recognized by “readers”, which are involved in multiple processes of RNA metabolism, such as primary miRNA processing, alternative splicing, mRNA stabilization, translation, and degradation.