Table 2. Inhibition of Cytosolic Delivery^a.

	Ib	Tc	condd	MICe (μM)	IC50f (μM)	RV50g (μM)
1h	2	31	P	800	>5000	4400
2	2	28	P	>50	>100	>100
3h	3	31	P	200	>1000	1300
4	3	28	P	5	60	>1000
5i	3	32	P	250	550
6	3	31	C	3	35	>1000
7	15	31	C	1.5	22	>500
8	11	31	P	1.5	9	>20
9	11	31	C	<5	>50	>50
10	11	28	C	<1	>50	>50
11	12	31	C	<1	7	>50
12	12	28	C	5	60	100
13	4	28	C	0.3	≈15	>5
14	33	28	C	1	>5	>5
15	34	31	P	3	>100	>100
16	34	31	C	16	>100	>100
17	34	28	C	1	26	>50
18	35	31	C	9	51	>100
19	35	28	C	4	25	>50
20	45	31	P	<1	10	>20
21	45	31	C	2	8	>20
22i	45	32	P	>100	>100
23	45	28	P	1	8	>20
24	36	31	C	2	27	>50
25	37	31	C	7	≈60	>50
26	38	31	C	23	47	>50
27	39	31	C	14	≈60	>50
28	40	31	C	8	50	>50
29	46	31	C	<2	49	>100
30h	47	31	P	≤0.1	1.3	35
31	47	28	P	>10	>10	>10
32i	47	32	P	2	50
33j	48	31	P	<1	4	>20
34j	49	31	P	4	40	60
35i	49	32	P	0.3	10
36	49	28	P	9	53	>50
37	41	28	C	1	8	>50
38	42	28	P	2	5	22
39	43	28	P	4	>50	43
40	44	28	P			4

^aFrom HCHT imaging of HK cells incubated first with

^binhibitors I at varied concentrations for 1 h and then with

^ctransporters T at the constant concentration (28, 5 μM; 31, 10 μM; 32, 0.5 or 1 μM) for 30 min, reporting fluorescence intensity of T inside intact, PI negative cells.

^dConditions: P = pre-incubation: I removed before addition of T. C = co-incubation: I not removed before addition of T.

^eConcentration needed to reach 15% inhibition.

^fConcentration needed to reach 50% inhibition. SEM ≤ 30%.

^gConcentration needed to lower relative viability (RV) by 50%. RV: number of PI negative cells divided by HOE-positive cells. SEM ≤ 30%.

^hData from ref (51).

ⁱData from ref (52).

^jData from ref (79).