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(A) A three dimensional model of the ACU193 Fab, depicting the heavy and light variable regions with locations of the CDRs, the sequences of which have been published (Goure et al., 2015, 2016; Gaspar et al., 2016). (B) A three dimensional model of the IgG2m4 Fc region. The four amino acid changes (highlighted in red) reduce complement activation and antibody-dependent cellular cytotoxicity (An et al., 2009; Strohl, 2010).
