FIGURE 1.

Modeling of the RBD‐ACE2 interaction. (a) The trimeric assembly of SARS‐CoV‐2 spike protein in complex with human ACE2 protein. Out of three spike proteins, two (blue and red surface) have their RBD buried (RBD down) and one (white surface) is with an exposed RBD (RBD up) conformation which binds at one end of human ACE2 (light green cartoon). (b) ACE2 interacts with amino acids of RBD (white ribbon) through its α1 helix (green ribbon). (c) The structures and sequences of the truncated α1 and five modified peptides. The amino acids at positions 28, 32, 36, and 40 are shown in sticks. The details of mutation and attachment of stapling agents are listed in Table 1