Table 1.
Minimum Inhibitory Concentration Values for Candida glabrata Isolates for Different Antifungal Agents With Clinical and Laboratory Standards Institute Interpretations
| Drug | Susceptibility (MIC, µg/mL) and Clinical Interpretation | |||||||
|---|---|---|---|---|---|---|---|---|
| Isolate 1 | Isolate 2 | Isolate 3 | Isolate 4 | |||||
| MIC | Int. | MIC | Int. | MIC | Int. | MIC | Int. | |
| Caspofungin | ≤0.25 | S | 0.25 | I | 0.5 | R | 0.5 | I |
| Fluconazole | 4 | S | 256 | R | >256 | R | 64 | R |
| Voriconazole | 0.25 | NA | 4 | NA | >8 | NA | ||
| Anidulafungin | 0.12 | S | 0.5 | R | 1 | R | ||
| Rezafungin | 2 | NA | ||||||
| Micafungin | 0.03 | S | 0.12 | I | 0.5 | R | ||
| 5-flucytosine | ≤0.06 | NA | ≤0.06 | NA | ||||
| Posaconazole | 1 | NA | >8 | NA | ||||
| Itraconazole | 1 | NA | >16 | NA | ||||
| Amphotericin B | ≤0.12 | NA | 1 | NA | 0.5 | NA |
Isolate 1: aortic graft explant in 2017; Isolate 2: thoracic duct embolization coil in 2019; Isolate 3: first aortic Dacron graft explant tissue isolate; Isolate 4: second aortic Dacron graft explant tissue isolate in 2020 (48-hour MIC data are reported due to insufficient growth at 24 hours; isolate possesses FKS2 D666Y mutation).
Abbreviations: I, intermediate; MIC, minimum inhibitory concentration; NA, not applicable; R, resistant; S, susceptible.