Table 1.
Cohort Demographics
| Characteristic | Overall
(N = 204) |
Cohort A
(n = 129) |
Cohort B
(n = 75) |
P Value |
|---|---|---|---|---|
| Age, y, mean (SD) | 51.13 (13.83) | 53.70 (12.65) | 46.72 (14.71) | <.001 |
| Sex | ||||
| Female | 85 (41.7) | 55 (42.6) | 30 (40.0) | .769 |
| Male | 119 (58.3) | 74 (57.4) | 45 (60.0) | |
| Primary disease | ||||
| Acute myeloid leukemia | 85 (41.7) | 57 (44.2) | 28 (37.3) | .152 |
| Myelodysplastic syndrome | 33 (16.2) | 22 (17.1) | 11 (14.7) | |
| Acute lymphocytic leukemia | 14 (6.9) | 7 (5.4) | 7 (9.3) | |
| Non-Hodgkin lymphoma | 39 (19.1) | 21 (16.3) | 18 (24.0) | |
| Multiple myeloma | 7 (3.4) | 3 (2.3) | 4 (5.3) | |
| Aplastic anemia | 3 (1.5) | 0 (0.0) | 3 (4.0) | |
| Solid organ malignancy | 1 (0.5) | 0 (0.0) | 1 (1.3) | |
| Other | 22 (10.8) | 19 (14.7) | 3 (4.0) | |
| HCT conditioning | ||||
| Myeloablative | 70 (34.3) | 28 (21.7) | 42 (56.0) | <.001 |
| Reduced intensity | 134 (65.7) | 101 (78.3) | 33 (44.0) | |
| HCT source | ||||
| Matched related donor | 67 (32.8) | 40 (31.0) | 27 (36.0) | <.001 |
| Unrelated donor | 118 (57.8) | 87 (67.4) | 31 (41.3) | |
| Haploidentical | 16 (7.8) | 2 (1.6) | 14 (18.7) | |
| Cord | 3 (1.5) | 0 (0.0) | 3 (4.0) | |
| Unrelated donor HLA mismatch | ||||
| No (matched) | 72 (61.0) | 47 (54.0) | 25 (80.6) | .010 |
| Yes (mismatched) | 46 (39.0) | 40 (46.0) | 6 (19.4) | |
| Antithymocyte globulin | ||||
| No | 94 (46.1) | 48 (37.2) | 46 (61.3) | .001 |
| Yes | 110 (53.9) | 81 (62.8) | 29 (38.7) | |
| Post-HCT parameters | ||||
| Median days to engraftment | 17 | 17 | 17 | .796 |
| Engraftment failure >30 d | 2 (1.0) | 0 | 2 (2.7) | NA |
| Relapse at day 180, % (95% CI) | 14.5 (10.0–19.7) | 13.4 (8.1–19.9) | 16.4 (8.9–25.8) | .299 |
| Grade II–IV aGVHD at day 100, % (95% CI) | 22.6 (17.1–28.5) | 17.8 (11.8–24.9) | 30.7 (20.6–41.4) | .02 |
Data are presented as No. (%) unless otherwise indicated.
Abbreviations: aGVHD, acute graft-vs-host disease; CI, confidence interval; HCT, hematopoietic cell transplant; NA, not applicable; SD, standard deviation.