Table 2.
Cumulative Incidence of Breakthrough Invasive Fungal Disease (IFD), Fungal-Free Survival, Proven/Probable IFD, and Proven/Probable IFD Combined With Possible/Suspected IFD at 180 Days
| Cohort | No. | Survival Rate/Cumulative Incidence, % (95% CI) | P Value |
|---|---|---|---|
| Breakthrough proven/probable IFD with competing risk of death | |||
| Total | 204 | 1.0 (.2–3.4) | |
| Cohort A | 129 | 1.6 (.3–5.1) | .306 |
| Cohort B | 75 | 0 | |
| Fungal-free survival (proven/probable) | |||
| Total | 204 | 83.1 (77.2–87.7) | |
| Cohort A | 129 | 85.2 (77.7–90.3) | .057 |
| Cohort B | 75 | 79.7 (68.6–87.2) | |
| Proven/probable IFD with competing risk of death | |||
| Total | 204 | 3.0 (1.2–6.0) | |
| Cohort A | 129 | 1.6 (.3–5.0) | .124 |
| Cohort B | 75 | 5.5 (1.7–12.4) | |
| Proven/probable IFD with competing risk of death and GVHD | |||
| Total | 204 | 2.0 (.7–4.7) | |
| Cohort A | 129 | 1.6 (.3–5.0) | .563 |
| Cohort B | 75 | 2.9 (.5–9.0) | |
| Proven/probable IFD combined with possible/suspected IFD with competing risk of death | |||
| Total | 204 | 5.4 (2.9–9.2) | |
| Cohort A | 129 | 1.6 (.3–5.0) | .002 |
| Cohort B | 75 | 12.2 (6.0–20.9) | |
| Proven/probable IFD combined with possible/suspected IFD with competing risk of death and GVHD | |||
| Total | 204 | 3.5 (1.5–6.7) | |
| Cohort A | 129 | 1.6 (.3–5.0) | .053 |
| Cohort B | 75 | 6.8 (2.5–14.2) |
Abbreviations: CI, confidence interval; GVHD, graft-vs-host disease; IFD, invasive fungal disease.