Table 4.
Univariable and Multivariable Analysis of Risk Factors for Fungal-Free Survival (Alive Without Proven/Probable Invasive Fungal Disease)
| Variable | Univariable | Multivariable | ||||||
|---|---|---|---|---|---|---|---|---|
| HR | Lower 95% CI | Upper 95% CI | P Value | HR | Lower 95% CI | Upper 95% CI | P Value | |
| Age | 1.013 | .993 | 1.033 | .213 | … | … | … | |
| Antithymocyte globulin | 1.386 | .826 | 2.327 | .217 | … | … | … | |
| Cohort B (vs A) | 1.630 | .981 | 2.708 | .060 | 1.520 | .868 | 2.663 | .143 |
| Male sex (vs female) | 0.978 | .585 | 1.634 | .932 | … | … | … | |
| Conditioning: RIC (vs MAT) | 1.189 | .689 | 2.050 | .534 | … | … | … | |
| Donor source (vs MRD) | ||||||||
| Unrelated donor | 1.721 | .946 | 3.132 | .075 | 1.669 | .912 | 3.052 | .097 |
| Haploidentical | 1.589 | .577 | 4.378 | .370 | 1.558 | .539 | 4.509 | .413 |
| Cord | 2.416 | .317 | 18.390 | .394 | 1.954 | .248 | 15.380 | .525 |
| Mismatch (vs matched) | 1.154 | .630 | 2.113 | .643 | … | … | … | |
| Primary disease (vs lymphoma) | ||||||||
| AML/MDS | 1.596 | .768 | 3.315 | .210 | 1.567 | .745 | 3.297 | .236 |
| ALL | 1.666 | .511 | 5.425 | .397 | 1.497 | .455 | 4.923 | .507 |
| Other | 2.148 | .890 | 5.185 | .089 | 2.275 | .924 | 5.601 | .074 |
| Grade II–IV GVHD (time dependent) | 2.291 | 1.336 | 3.929 | .003 | 2.035 | 1.155 | 3.587 | .014 |
Outcome events: death or proven/probable invasive fungal disease.
Abbreviations: ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; CI, confidence interval; GVHD, acute graft-vs-host disease; HR, hazard ratio; MAT, myeloablative conditioning; MDS, myelodysplastic syndrome; MRD, matched related donor; RIC, reduced intensity conditioning.