Table 2.
Laboratory and imaging findings of the patients
| Characteristics | FVP group (n = 32) | LPV/RTV group (n = 31) | p | |
|---|---|---|---|---|
| Hematologic, ×109/L | ||||
| Hematocrit | Baseline | 36.51 ± 3.84 | 34.43 ± 7.20 | 0.166 |
| Day 7 | 36.58 ± 3.95 | 33.26 ± 4.17 | 0.021 | |
| WBC | Baseline | 8.49 ± 4.10 | 6.45 ± 2.89 | 0.027 |
| Day 7 | 7.78 ± 3.32 | 8.61 ± 4.07 | 0.568 | |
| Neutrophil | Baseline | 74.51 ± 9.56 | 75.32 ± 10.34 | 0.748 |
| Day 7 | 71.31 ± 21.32 | 81.81 ± 8.22 | 0.108 | |
| Lymphocytes | Baseline | 16.80 ± 8.02 | 18.83 ± 9.08 | 0.351 |
| Day 7 | 15.36 ± 9.29 | 12.09 ± 8.07 | 0.257 | |
| Platelets | Baseline | 195.47 ± 72.02 | 208.67 ± 60.77 | 0.440 |
| Day 7 | 246.77 ± 116.01 | 242.31 ± 99.62 | 0.901 | |
| Biochemical | ||||
| Hemoglobin, g/L | Baseline | 12.53 ± 1.77 | 11.45 ± 1.87 | 0.022 |
| Day 7 | 11.94 ± 1.53 | 10.75 ± 1.54 | 0.027 | |
| BNU, mg/dl | Baseline | 31.28 ± 8.77 | 38.07 ± 15.25 | 0.047 |
| Day 7 | 37.31 ± 6.82 | 46.29 ± 20.96 | 0.081 | |
| Creatinine, mg/dl | Baseline | 1.04 ± 0.21 | 1.31 ± 0.44 | 0.005 |
| Day 7 | 1.16 ± 0.24 | 1.17 ± 0.27 | 0.927 | |
| ALT, units/L | Baseline | 44.90 ± 13.28 | 47.13 ± 21.27 | 0.628 |
| Day 7 | 49.50 ± 13.92 | 64.58 ± 34.67 | 0.419 | |
| AST, units/L | Baseline | 44.07 ± 12.48 | 54.97 ± 43.49 | 0.196 |
| Day 7 | 42.75 ± 16.86 | 50.67 ± 22.30 | 0.529 | |
| LDH, units/L | Baseline | 540.41 ± 299.70 | 610.97 ± 307.01 | 0.360 |
| Day 7 | 599.33 ± 216.18 | 747.26 ± 303.35 | 0.224 | |
| CRP (>3 mg/dl) | Baseline | 22 (68.8) | 16 (51.6) | 0.203 |
| Coagulation function | ||||
| APTT, s | Baseline | 34.64 ± 5.43 | 39.72 ± 9.27 | 0.018 |
| Day 7 | 47.00 ± 15.56 | 35.23 ± 9.83 | 0.148 | |
| Pt, s | Baseline | 14.45 ± 6.30 | 13.93 ± 2.31 | 0.680 |
| Day 7 | 14.70 ± 1.51 | 13.58 ± 1.34 | 0.209 | |
| INR | Baseline | 1.07 ± 0.09 | 1.16 ± 0.32 | 0.194 |
| Day 7 | 1.65 ± 0.84 | 1.07 ± 0.16 | 0.356 | |
| Imaging | ||||
| Ground‐glass pattern | Baseline | 31 (96.9) | 31 (100.0) | 0.999 |
| Day 7 | 12 (70.6) | 28 (84.3) | 0.011 | |
| Consolidation | Baseline | 13 (40.6) | 29 (93.5) | 0.001 |
| Day 7 | 5 (29.4) | 26 (92.9) | <0.001 |
Note: Values were expressed as mean ± SD, median (IQR), or n (%).
Comparison between groups was performed using the t‐test, the Mann–Whitney U‐test, or the Fisher's exact test.
Abbreviations: ALT, alanine aminotransferase; APTT, activated partial thromboplastin time; AST, aspartate aminotransferase; BUN, blood nitrogen urea; CRP, C‐reactive protein; FVP, favipiravir; INR, international normalized ratio; LDH, lactate dehydrogenase; LPV/RTV, lopinavir/ritonavir; PT, prothrombin time; WBC, white blood cell.