TABLE 2.
PAEs against M. tuberculosis H37Rv after a 2-h exposure to single drugs and combinations of drugs, determined by the BACTEC T100 method
| Drug(s)a | MIC (mg/liter) | PAE (h)b | % CV |
|---|---|---|---|
| Isoniazid | 0.06 | 18.1 (5.7–31.2) | 46 |
| Rifampin | 0.5 | 67.8 (11.9–134.9) | 70 |
| Streptomycin | 1.0 | 32.2 (0.7–60.2) | 93 |
| Pyrazinamide | ≤50c | 1.9 (0.0–5.2) | 153 |
| Ethambutol | 2.0 | 1.8 (0.0–5.6) | 139 |
| Amikacin | 1.0 | 17.4 (13.0–19.9) | 22 |
| Ofloxacin | 0.25 | 6.2 (0.0–12.4) | 142 |
| HR | 159.8 (114.4–220.0) | ||
| HRS | 160.6 (97.0–275.1) | ||
| HRM | 155.3 (89.7–215.6) | ||
| HRSZ | 167.9 (72.6–286.9) | ||
| HRSM | 135.5 (90.3–202.8) | ||
| HRZM | 125.9 (90.0–176.1) | ||
| HRA | 97.2 (94.1–100.3) | ||
| ORA | 95.0 (94.3–95.8) |
a
Abbreviations used for combinations: H, isoniazid; R, rifampin; S, streptomycin; Z, pyrazinamide; M, ethambutol; A, amikacin; O, ofloxacin.
b
Values are means (ranges).
c
The breakpoint concentration used to determine susceptibility to pyrazinamide by the absolute concentration method.