Dose, mode of administration and sampling time in the process of screening and validating biomarkers.

Grouping	Drug	Num	Dose	Mode	Time
Control group	Distilled water	9	2.5 ml	ai.g., successive administration	7 days
Low dose group	Cortex Periplocae	9	3 g kg−1 d−1	ai.g., successive administration	7 days
Middle dose group	Cortex Periplocae	9	6 g kg−1 d−1	ai.g., successive administration	7 days
High dose group	Cortex Periplocae	9	9 g kg−1 d−1	ai.g., successive administration	7 days

^aIntragastric administration.