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. 2018 Oct 23;8(63):36076–36089. doi: 10.1039/c8ra06707d

Percentage levels of degradation of indapamide and dihydralazine under high temperature/high humidity and UV/VIS light.

Conditions Level of degradation [%]
Indapamide Dihydralazine
Individual Mixture Individual Mixture
Degradation in a solid state
70 °C/80% RH 1.05 14.69 21.68 26.15
1ICHa 1.76 1.87 1.45 5.98
3ICHa 3.86 3.95 8.62 23.14
6ICHa 7.15 8.23 25.78 48.76
Degradation in solutions
1ICHa 17.52 17.97 2.78 21.08
3ICHa 32.38 34.15 12.98 41.15
6ICHa 67.16 69.88 100.0 100.0
a

1ICH = 18 902 kJ m−2; 3ICH = 56 706 kJ m−2; 6ICH = 113412 kJ m−2.