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. 2022 Apr 4;2(4):1007–1017. doi: 10.1021/jacsau.2c00130

Figure 3.

Figure 3

Labeling of live and fixed islets of Langerhans with LUXendin492, LUXendin551, and LUXendin615. (A) Incubation of live islets with LUXendin492 (LUX492), LUXendin551 (LUX551), or LUXendin615 (LUX615) leads to bright staining confined to the cell membrane (scale bar = 53 μm) (n = 11–13 islets from 4 mice). (B) LUXendin492, LUXendin551, and LUXendin615 signals can still be detected following formalin fixation and are co-localized with orthogonal emission from a specific monoclonal antibody against GLP1R (mAb) (scale bar = 85 μm) (n = 9–10 islets from 4 mice).