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. 2022 Apr 26;13:871769. doi: 10.3389/fimmu.2022.871769

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Copyright © 2022 Sun, Zhou, Guan, Liu, Yang, Wang, Gan, Zhou, Fan, Yi and Qiu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of cellular interactions between P-ICC and T-ICC. (A) Bar plots displaying the sum of number (left) and weights (right) of ligand–receptor interactions between P-ICC and T-ICC. Circle plots (B) and heatmap (C) showing the differential number (left) and strength (right) of ligand–receptor interactions between distinct cellular components. Clusters are distinguished by colors. Red connecting lines indicated upregulated number or strength. The blue lines indicated reduced number or strength. (D) Heatmap showing the differential overall signaling patterns of cell types in P-ICC and T-ICC. (E) Dot plots showing the increased (left) and decreased (right) signaling effects of malignant cells on other cell types, respectively. Circle plots showing the VEGF-related signaling networks in P-ICC (F) and T-ICC (G). P-ICC, primary ICC; T-ICC, ICB-treated ICC.