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. 2022 Apr 26;13:871769. doi: 10.3389/fimmu.2022.871769

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Copyright © 2022 Sun, Zhou, Guan, Liu, Yang, Wang, Gan, Zhou, Fan, Yi and Qiu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SPP1⁺ TAMs correlate with poor prognosis in ICC. (A) Circle plots showing signaling networks of the ligand–receptor (SPP1-CD44) in P-ICC (left) and T-ICC (right). (B) t-SNE plots showing the CD68, CD163, SPP1, and CD44 expression levels in all cells of ICC samples. (C) Representative microphotographs of SPP1⁺CD68⁺ TAMs. White arrow indicates positive staining of SPP1 and CD68. (D) Kaplan–Meier survival curves for OS (left) and RFS (right) of patients with ICC grouped by infiltration levels of SPP1⁺ TAMs. P-values were determined via the log-rank test. OS, overall survival; RFS, recurrence-free survival; TAMs, tumor-associated macrophages.