Table 3.

Multivariate cox regression analysis of variables associated with recurrence and overall survival in the ZSH cohort.

Variables	Recurrence		Overall survival
	HR (95% CI)	P	HR (95% CI)	P
Microvascular invasion (yes versus no)	1.571 (1.008–2.449)	0.046	1.808 (1.262–2.590)	0.001
LN metastasis (yes versus no)	N.A.	N.A.	2.964 (0.909–9.664)	0.072
No. of tumors (multi versus single)	0.926 (0.594–1.444)	0.735	0.990 (0.661–1.482)	0.960
Tumor size (>5 cm versus ≤5cm)	1.719 (1.132–2.611)	0.011	1.116 (0.768–1.622)	0.564
CA199 (>37 U/ml versus ≤37 U/ml)	1.271 (0.868–1.861)	0.217	1.474 (1.046–2.077)	0.027
CEA (>5 ng/ml versus ≤5 ng/ml)	1.132 (0.734–1.745)	0.574	1.909 (1.346–2.709)	<0.001
GGT (>60 U/l versus ≤60 U/l)	1.454 (1.000–2.115)	0.050	1.675 (1.174–2.389)	0.004
AJCC 8th (IIIa–IIIb versus I–II)	N.A.	N.A.	0.814 (0.253–2.620)	0.730
SPP1+ TAMs (high versus low)	2.613 (1.805–3.783)	<0.001	1.701 (1.225–2.361)	0.002

HR, hazard ratio; CI, confidence interval; NA, not available.

Bold indicated statistical significance.